![]() ![]() Many plants such as barley have the A chain but not the B chain. Ricin B is a lectin that binds galactosyl residues and is important in assisting ricin A's entry into a cell by binding with a cell surface component.Ricin A is an N- glycoside hydrolase that specifically removes an adenine base from ribosomal RNA, resulting in an inhibition of protein synthesis.Ricin consists of two distinct protein chains (almost 30 kDa each) that are linked to each other by a disulfide bond: The case experience is not as negative as popular perception would indicate. A solution of saline and glucose has been used to treat ricin overdose. Eight beans are considered toxic for an adult. (See abrin).ĭeaths caused by ingestion of seeds are rare. Ricin causes severe diarrhea and victims can die of shock. Long term organ damage is likely in survivors. Symptomatic and supportive treatment is available. While there is no known antidote, the US military has developed a vaccine. Ricin is poisonous if inhaled, injected, or ingested, acting as a toxin by the inhibition of protein synthesis. The A chain is shown in blue and the B chain in orange. Risk calculators and risk factors for Ricin ![]() US National Guidelines Clearinghouse on Ricin Articles on Ricin in N Eng J Med, Lancet, BMJ ![]()
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